Synthesis, antimicrobial, antioxidant, and ADMET studies of quinoline derivatives
نویسندگان
چکیده
منابع مشابه
antioxidant and antimicrobial activity of allium jesdianum extract
چکیده بررسی فعالیت ضد اکسیدانی و ضدمیکروبی عصاره گیاه بن سرخ (allium jesdianum) به کوشش: زهرا مقیمی هدف از این تحقیق بررسی میزان ترکیبات فنولی کل، ترکیبات فلاوونوئیدی کل، فعالیت ضداکسیدانی و ضدمیکروبی عصاره ی گیاه تازه و خشک بن سرخ بود. استخراج عصاره به روش های غوطه وری، استفاده از همزن مغناطیسی، دستگاه مایکروویو، امواج فراصوت و گرمادهی مقاومتی و با استفاده از متانول، اتانول و آب به عنوا...
Synthesis, characterization and antimicrobial screening of novel quinoline-thiazole derivatives
2-Chloroquinoline-3-carbaldehyde 1 reacts with 2-cyanoacetohydrazide in ethanol to result in 1-[1-aza-2-(2-chloro(3quinolyl))vinyl]-2-cyanoacetamide 2. Phenyl isothiocyanate added to a stirred solution of compound 2, sulphur and triethylamine in a mixed solvent of dimethylformamide : ethanol to result in N-[1-aza-2-(2-chloro(3-quinolyl))vinyl](4amino-3-phenyl-2-thioxo(1,3-thiazoline-5-yl)) carb...
متن کاملDesign, Synthesis and Antimicrobial Evaluation of Some Novel Quinoline Derivatives
The Global Burden of Disease Study(GBDS) estimates that infectious diseases were responsible for 22% of all deaths and 27% of disability-adjusted life years (DALYS ) worldwide according to WHO [1]. Antimicrobial resistance among clinically important bacteria is widely acknowledged as a major global public health threat [2]. Most of the currently used antimicrobial drugs are associated with adve...
متن کاملSynthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier-Haack reaction.
The study of the Vilsmeier-Haack reagent on 4-hydroxyquinaldines resulted in a new versatile intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl)quinolines, which on further treatment with hydrazine hydrate yielded the desired diazepino quinoline derivatives. All the synthesized diazepino quinoline derivatives are screened for their antibacterial and antifungal activities. Cytogenetic analy...
متن کاملSynthesis and characterization of carbazole derivatives and their antimicrobial studies.
The reaction of 1-oxo-1,2,3,4-tetrahydrocarbazoles (1a-e) with paraformaldehyde and ethylenediamine yielded N,N'-bis(1,2,3,4-tetrahydrocarbazol-1-ylidene)ethane-1,2-diamines (2a-e). Here, like in another similar attempt of replacing ethylenediamine by ethanolamine, ended up in formation of 2-{[1-(2-(2-aminoethoxy)ethylimino)-1,2,3,4-tetrahydrocarbazol-2-yl-methyl]amino}ethanols (3a-e). These pr...
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ژورنال
عنوان ژورنال: European Journal of Chemistry
سال: 2021
ISSN: 2153-2257,2153-2249
DOI: 10.5155/eurjchem.12.1.37-44.2038